Lay Summary
The neurons of the nervous system form enormously complicated networks that are specific but also modifiable to an extent. The specificity of the connections allows functional modules to develop, like the circuit that regulates the knee-jerk reflex. On the other hand, modifications of connectivity ensure circuits can adapt. This allows us to learn and remember, or heighten our perception of food odours when hungry.
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Controlled regulation of a system of structural polymers that form the internal skeleton of cells, the cytoskeleton, is critical for neurons to extend axons and dendrites and form connections with their targets. This system also regulates the physical changes in neuronal connections. Regeneration of neurons after an injury is also dependent on this system. We investigate how the neuronal cytoskeleton is regulated during the process of developing neuronal circuits and during changes in connectivity.
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Another mode of changing circuit function is modifying the functional connection between neurons - how sensitive is the neuron to the incoming signal, for example. We explore how small peptides modify circuit activity and therefore animal behaviour. Specifically, we look at how physiological changes (like whether the animal is hungry or sated) uses these molecules to optimise behaviours.