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Development and Plasticity of Neural Circuits

 

We investigate cytoskeleton remodelling in neuronal morphogenesis & structural plasticity of neural circuits, along with adaptive prioritisation of circuit function by neuropeptide signalling. Quantitative cell biology, biophysical measurements, activity imaging and behavioural analysis are the mainstays of the group. Our Research >> 

Selected Publications View all publications >>

(preprint) The actin-associated protein Kaptin modulates F-actin barbed-end dynamics.

Dutta P, Maiti I, Ghose A, Chauhan R and Maiti S

bioRxiv, 2023, doi: 10.1101/2023.10.30.564586

Convergent energy state-dependent antagonistic signalling by Cocaine- and amphetamine-regulated transcript and Neuropeptide Y modulates the plasticity of forebrain neurons to regulate feeding in zebrafish.

Bodas DS*, Maduskar A*, Kaniganti T, Wakhloo D, Balasubramanian A, Subhedar N and Ghose A 

J Neurosci, 2023, 43(7):1089-1110. doi: 10.1523/JNEUROSCI.2426-21.2022 

(also bioRxiv, doi: 10.1101/2021.10.21.465223)

* equal contribution

The role of mechanics in axonal stability and development.

Ghose A and Pullarkat P 

Sem Cell Dev Biol, 2023, 140, 22-34, doi: 10.1016/j.semcdb.2022.06.006

 

Antagonistic activities of Fmn2 and ADF regulate axonal F-actin patch dynamics and the initiation of collateral branching.

Kundu T, Das SS, Sewatkar LK, Kumar DS, Nagar D and Ghose A

J Neurosci, 2022, 42(39), 7355-7369. doi: 10.1523/JNEUROSCI.3107-20.2022

(also bioRxiv, doi: 10.1101/2020.11.16.384099)

(preprint) Development of motor neurons and motor activity in zebrafish requires F-actin nucleation by Fmn2b.

Nagar D, Carrington B, Burgess SM and Ghose A

bioRxiv, 2021, doi: 10.1101/2021.08.10.455777

 

Sensitivity of Olfactory Sensory Neurons to food cues is tuned to nutritional states by Neuropeptide Y signalling.

Kaniganti T*, Deogade A*, Maduskar A, Mukherjee A, Guru A, Subhedar N, Ghose A

J Neurochem, 2021, 159(6), 1028-1044. doi: 10.1111/jnc.15488 (also bioRxiv, doi: 10.1101/573170)

* equal contribution

The formin Fmn2b is required for the development of an excitatory interneuron module in the zebrafish acoustic startle circuit.

Nagar D, James TK, Mishra R., Guha S, Ghose A

eNeuro, 2021, 8(4) doi: 10.1523/ENEURO.0329-20.2021 (also bioRxiv, doi: 10.1101/2020.07.23.218032)

 

Coupling of dynamic microtubules to F-actin by Fmn2 regulates chemotaxis of neuronal growth cones.

Kundu T*, Dutta P*, Nagar D, Maiti S, Ghose A 

J Cell Sci, 2021, 134(13) doi: 10.1242/jcs.252916 (also bioRxiv, doi: 10.1101/2020.01.18.911131)

* equal contribution

Transient systemic inflammation in adult male mice results in underweight progeny.

Rokade S,  Upadhya M, Bhat DS, Das A,  Subhedar N, Yajnik CS, Ghose, A, Rath S, Bal V

Am J Repro Immunol, 2021, 86, e13401. doi: 10.1111/aji.13401 (also bioRxiv, doi: 10.1101/2020.10.30.358697)

 

Fmn2 regulates growth cone motility by mediating a molecular clutch to generate traction forces.

Ghate K, Mutalik SP, Sthanam, LK, Sen S, Ghose A 

Neuroscience, 2020, 48, 160-171 (also bioRxiv, doi: 10.1101/2020.02.21.959759)

The axonal actin-spectrin skeleton acts as a tension buffering shock absorber.

Dubey S, Bhembre N, Bodas S., Veer S, Ghose A, Callan-Jones A, Pullarkat PA 

eLife, 2020, 9:e51772, doi: 10.7554/eLife.51772 (also bioRxiv, doi: 10.1101/510560)

Axonal cytomechanics in neuronal development.

Mutalik SP,  Ghose A 

J Biosci, 2020, 45, 64 (pdf

Cytoskeletal mechanisms of axonal contractility.

Mutalik SP, Joseph J, Pullarkat PA, Ghose A

Biophys J, 2018, 115(4), 713-724 (also bioRxiv, doi: 10.1101/227777)

cAMP signaling mediates behavioral flexibility and consolidation of social status in Drosophila aggression.

Chouhan NS, Mohan K, Ghose A 

J Exp Biol, 2017, 220, 4502-4514 (also bioRxiv, doi: 10.1101/089979)

CART neuropeptide modulates the extended amygdalar CeA-vBNST circuit to gate expression of innate fear.

Rale A, Shendye N, Bodas DS, Subhedar N, Ghose A

Psychoneuroendocrinol, 2017, 85, 69-77 (also bioRxiv, doi: 10.1101/096610)

Formin-2 regulates stabilization of filopodial tip adhesions in growth cones and affects neuronal outgrowth and pathfinding in vivo.

Sahasrabudhe A, Ghate K, Mutalik S, Jacob A, Ghose A

Development, 2016, 143, 449-460

View all publications from the group >>

Support

IISER Pune intramural funding

Dept. of Biotechnology (DBT), Govt. of India

DBT/Wellcome Trust India Alliance

Science and Engineering Research Board (SERB), Govt. of India

Cognitive Science Research Initiative (CSRI), DST, Govt. of India

Council for Scientific and Industrial Research (CSIR), Govt. of India

Lady Tata Memorial Trust

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